
تامسول 0.4 مجم 30 كبسولة
Composition:Each modified-release capsule contains 0.4mg tamsulosin hydrochloride.
Indications And Usage:Treatment of urinary obstruction symptoms produced by benign prostatic hyperplasia.
Contraindications: Hypersensitivity to tamsulosin hydrochloride.
History of Postural hypotension.
Severe hepatic insufficiency.
Dosage & Administration:One capsule 0.4 mg daily, to be taken after breakfast.
The dose may be increased, if necessary, after 2-4 weeks, to 0.8 mg daily.
Drug Interactions:Concurrent administration of other alpha1- adrenoceptor blocker, antihypertensive, diuretics with tamsulosin could lead to hypotensive effects.
How Supplied:Strip contains 10 modified-release capsules in packs of one strip.
Precautions: As with other alpha1-blockers, reduction in blood pressure can occur in individual cases.
At the first signs of orthostatic hypotension (dizziness, weakness), the patient should lie down until the symptoms have disappeared.
During driving or operating machinery, patients should be aware of the fact that dizziness can occur.
Pharmacological Properties: Tamsulosin selectively blocks alpha-1 adrenoreceptors (alpha1A-adrenoreceptor subtype) in the prostate, resulting in relaxation of prostatic and urethral smooth muscles.
It is more selective than prazosin.
Tamsul® increases the maximum urinary flow rate.
It relieves obstruction by relaxing smooth muscle in prostate and urethra.
Side Effects:Dizziness, headache, asthenia, postural hypotension and palpitations may rarely occur.
Postural hypotension may be exaggerated by exercise, heat or alcohol ingestion.
Because tamsulosin is more selective on prostate than prazosin, it shows less dilator effect (postural hypotension) than that seen with prazosin.
So rarely, abnormal ejaculation may also occur.